Kabl schbanz



Patented Feb. 1, 1927.

' UNITED' STATES.

PA ENT CLIOFFIC-E.

m1. sc nm z, or ELBEnF-ELD, AND onnnnns LU'rrEn, OIJBABMENL-LANGERFELD, enaum assmnons 'ro wm'rnaor CHEMICAL comrm, nc on NEW YORK,

N.Y.' i

1an;rHoxYmnrnYL-a'z-nmmnimxnrrrnrim..

No Drawing. Application filed July 6,1925, Serial No. 41,870, and in Germany October 29, 1924.

' The present invention relates to the manufacture and production of a new pharmacew tically valuab e product being chemically the o Canaan The new 'product acts like caifein on the human body. It is more soluble in water than cafl'ein. It crystallizes from water in needles melting at from 168-170 C. and forms double salts with salts of organic acids, e. g. with sodium 'benzoate; sodium salicylate etc. y

In order to illustrate the new process more fullythe following example is given, the.

parts being. by weight.

A ure of 200 parts by weightof theobromine (sodiumsalt), 200 parts by weight of benzene and 90 parts by weight of chloromethylether is heated an autol-methoxymethyl-3.7 dimethylxanthine 5 having most probably the following formula set our hands.

'clave during 3 hours to 120 C. The lmeth0xymethyl-3.7 -dimetl 1yl'xanthine is 'ziso- 95/ lated. by extraction with benzene and crys tallized I from water .or alcohol. Theobromine itselfcan also be-used.

We claim 2- v i 1. The process of producing .l-niethox- 30 ymethyl-3.7-dimethylxanthine', which pro.-

ce ss consists in treating a theobromine salt with chloromethylether, substantially as described.

2; The herein described l-methoxymethyl- 35 3.7-dilnethylxanthine crystallizing from water in the shape of needles melting at 1 68-170 0., formingdoub'le salts with salts (if organic acids and showing a cafl'ein like action on the human body, substantially as described. j

In testimony whereof we have hereunto KARL sHRANzLfi CLEMENS I LUTTER. 

